Empirical Evaluation of Thyroid Function and Ovarian Reserve
Authors
Makhmudova Fotima Ravshanovna, Nasirova Khurshidakhon Kudratullaevna
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This study empirically investigated the relationship between thyroid function and ovarian reserve in women of reproductive age, incorporating key hormonal markers and inflammatory indicators. A one-way Analysis of Variance (ANOVA) was conducted to compare three distinct groups: the control group (practically healthy women, n=20), women with decreased ovarian reserve (DOR) and hypothyroidism (n=40), and women with DOR and euthyroidism (n=40). Data on Thyroid-Stimulating Hormone (TSH), Anti-Müllerian Hormone (AMH), Follicle-Stimulating Hormone (FSH), C-reactive protein (CRP), Complement C3, and Ceruloplasmin were analyzed. Significant differences were observed across groups for TSH (F(2,97)=54.245,p<.001), AMH (F(2,97)=323.365,p<.001), CRP (F(2,97)=101.497,p<.001), Complement C3 (F(2,97)=34.264,p<.001), and Ceruloplasmin (F(2,97)=46.734,p<.001). Post-hoc analyses revealed significantly higher TSH and lower AMH in the group with DOR and hypothyroidism compared to both the control group and the group with DOR euthyroidism. CRP, Complement C3, and Ceruloplasmin were also markedly elevated in the DOR with hypothyroidism group, suggesting an inflammatory component. FSH and age did not show significant inter-group differences. These findings underscore the critical impact of thyroid dysfunction on ovarian reserve and highlight the potential role of inflammatory markers in compromised reproductive health.
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Authors
Makhmudova Fotima Ravshanovna, Nasirova Khurshidakhon Kudratullaevna
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References:
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