DEVELOPMENT OF A TECHNOLOGICAL SCHEME FOR THE SYNTHESIS OF PHENYL-3-METHYLPHENOXYPROPIONATE BY REACTION OF PHENYL-2-CHLOROPROPIONATE WITH 3-METHYLPHENOL
Authors
Ochilov Mansur, Abdushukurov Anvar Kabirovich, Mamatkulov Nematillo Narzullaevich, Rajabov Shohzodbek Holmuratovich
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The article presents nucleophilic substitution reactions of phenyl-2-chloropropionate with 3-methylphenol under various conditions and a method for preparing phenyl-3-methylphenoxypropionate. Nucleophilic substitution reactions were carried out in the solvents benzene, acetone, dioxane, DMF (Dimethylformamide), and DMSO (Dimethyl sulfoxide). It was found that these solvents affect the duration and yield of the reaction. In the reaction, phenyl-3-methylphenoxypropionate was obtained in a DMSO solution with a yield of 83%. A technological scheme for the synthesis of phenyl-3-methylphenoxypropionate in acetone was developed. The reason is that acetone is a cheap solvent and is convenient for the industrial production of organic substances. The structure of the synthesized new organic substance, phenyl-3-methylphenoxypropionate, was confirmed using modern IR, ¹HyAMR and 13CYaMR spectra.
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Authors
Ochilov Mansur, Abdushukurov Anvar Kabirovich, Mamatkulov Nematillo Narzullaevich, Rajabov Shohzodbek Holmuratovich
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References:
Ochilov M., Mamatkulov N. N., Abdushukurov A. K. Synthesis, characteristics and development of a process flow chart for obtaining phenyl 2-phenoxypropionate in an acetone medium // Universum: technical sciences: electronic scientific journal. 2025. 8(137). –P. 60-65. https://7universum.com/ru/tech/archive/item/20690.
Abdushukurov A. K., Yusufov M. S. Study of the reaction of isomeric aminophenols with chloroacetyl chloride // Universum: Technical sciences: electronic scientific journal. 2020. No. 3(72). P. 74-75. http://7universum.com/ru/tech/archive/item/9096.
Abdushukurov A. K., Mamatkulov N. N., Ibragimov T. E. 2-Isopropyl-5-Methylphenylchloroacetate Synthesis Method// Web of Synergy:International Interdisciplinary Research Journal. Volume 2 Issue 4, Year 2023. Pp. 687-691.
Mamatkulov N. N., Ochilov M., Tursunova D. R. 5- Methyl -2-(1-Methylethyl) Phenol with Chloroacetyl Chloride under Alkaline Conditions// Web of Semantic: Universal Journal on Ie Education. Volume 2 Issue 4, Year 2023. Pp. 73-76.
Azomova G.Z., Yuldasheva M. R., Tadjimuhamedov K. S. Influnce of a nanostructural catalyst in the synthesis of allulnaphthols//Austrian jurnal of technical and natural sciences. №5-6. Vena, 2020. Pp. 32-36.
Vartanyan R.S. Synthesis of essential drugs. Moscow: MIA, 2005. -180 p.
Sibrikov S.G. Pathways of pesticide transformation in living organisms. Moscow:, –(reprinted 2022). -220 p.
Mamatkulov N.N., Yakubov L E. Synthesis of o-tolylphenoxyastatin through a nucleophilic substitution reaction from o-toluoyl chloride and examination of its biological activity // Nat. Volatiles & Essent. Oils, 2021. -№ 8(5). -P. 12125-12131.
Mamatkulov N.N., Yakubov L. E. Madusmanova N.K., Khoshimkhanova M.A. Method for the Synthesis and Bioavailability of Phenol-4-Methoxyphenoxy-acetate by Nucleophilic Exchange Reaction // Nat. Volatiles & Essent. Oils, 2021. -№ 8(5). -P. 12140-12144.
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