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IR–SPECTROSCOPIC METHOD TO HELP IN CHEMICAL–TOXICOLOGICAL INVESTIGATION OF AMLODIPINE

Authors

Khairullo Kayumovich Olimov, Zukhra Akhmadovna Kholikova, Damir Iserkepovich Abadjanov

Rubric:Chemistry
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Diseases of the cardiovascular system are very common among the population today. According to statistics, 17 million people live in the world every yеar. One of the main reasons for this is acute heart rhythm disturbances, problems with high blood pressure. In particular, ventricular tachycardia and fibrillation of cardiac arrhythmias are very life–threatening. Therefore, in connection with life –threatening severe rhythm changes, such as tachycardia and irreversible ventricular fibrillation, the development of suitable antiarrhythmic drugs that can be fast and highly effective even in severe arrhythmias remains one of the urgent tasks of today. Based on this, the relevance of our work is the development of methods for separating amlodipine from a biological object, improvement of methods for analyzing the drug amlodipine, enalapril and metaprolol which is widely used in the treatment of hypertensive diseases.

Keywords

urine
methods of analysis
solvent system.
blood
hypertension
biological object
substance
tablet
drug

Authors

Khairullo Kayumovich Olimov, Zukhra Akhmadovna Kholikova, Damir Iserkepovich Abadjanov

References:

1. Mashkovsky M.D. Lekarstvennaya sredstva M., 2016. – p. 273, 427, 433.

2. American Pharmacopoeia (USP38–NF33. – p. 3290).

3. Ubaidullaev Q.A. Primenenie IR–spectrometer and farm analysis. – p. 248.

4. Ubaydullaev Q.A. “Validation of production of medicines”. T.: 2017. – p. 195.

5. Usmanalieva Z.U., M.A. Tojiev. Isolation and analysis of albendazole from biological fluids.

6. Nurmatova M.I., Yuldashev Z.A. Development of a thin layer chromatographic analysis method for imidacloprid and acetamiprid pesticides. Pharmaceutical Journal. №1., Tashkent, 2019. – p. 48.

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