SYNTHESIS OF A THIOUREA-CONTAINING COMPOUND VIA THE REACTION OF BENZOTHIOISOCYANATE WITH 6-AMINOQUINAZOLIN-4-ONE
Authors
Zulpanov Fazliddin Abduxakimovich, Khudoyberdiyeva Ozoda Otabek kizi, Otamurodov Muhriddin Rizomat ugli, Yakubov Ubaydullo Majidovich, Elmuradov Burkhon Juraevich
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In this study, the benzylation reactions of quinazolin-4-one were investigated. The influence of various factors such as temperature, solvent, and catalysts on the incorporation of the benzyl group and the overall reaction efficiency was analyzed. The structures of the synthesized benzyl derivatives were elucidated using modern physicochemical techniques (IR, NMR). Based on the obtained results, optimal reaction conditions were proposed. Furthermore, the biological activity of the benzylated quinazolin-4-ones was preliminarily evaluated, and several promising candidates were identified. These findings broaden the prospects for developing quinazolin-4-one derivatives as novel biologically active compounds and provide a foundation for their application in pharmaceuticals and agrochemistry.
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Authors
Zulpanov Fazliddin Abduxakimovich, Khudoyberdiyeva Ozoda Otabek kizi, Otamurodov Muhriddin Rizomat ugli, Yakubov Ubaydullo Majidovich, Elmuradov Burkhon Juraevich
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