TARGETED MODIFICATIONS OF 5,6-DISUBSTITUTED-4-CHLOROTHIENO[2,3-d]PYRIMIDINES WITH BENZYLAMINE
Authors
Khamraeva Guzal Ibragimovna, Valiev Yunusjon Yusup ugli, Berdiev Abdugani Umir ugli, Saitkulov Foziljon Ergashevich, Elmuradov Burkhon Zhuraevich
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Formed from two different components and covalently linked, hybrid blocks make it possible to achieve more effective results due to the fact that each molecule has specific properties that differ from those expected. This concept has been successfully used in the creation and production of hybrid drugs. The combination of chemically distinct pharmacophores in the form of a single molecule results in at least two or multiple manifestations of the hybrid molecule potential. Therefore, this article highlights the processes of joining two fragments with high biological activity – thienopyrimidine and benzylamine – as well as the synthesis of new hybrid molecules and the study of their structure using modern methods of physical and chemical analysis. The structures of the obtained compounds were elucidated using IR, 1H and 13C NMR spectroscopy. X-ray crystal structure analyses of the synthesized compounds were performed.
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Authors
Khamraeva Guzal Ibragimovna, Valiev Yunusjon Yusup ugli, Berdiev Abdugani Umir ugli, Saitkulov Foziljon Ergashevich, Elmuradov Burkhon Zhuraevich
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