In the original languageTranslation into English
SYNTHESIS AND BIOLOGICAL ACTIVITY OF HYDROCHLORID QUINAZOLIN-4-ONE
Authors
Saitkulov Foziljon Ergashevich, Elmuradov Burkhon Zhuraevich, Sapaev Bayramdurdi
Rubric:Chemistry
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Annotation
By the interaction of anthranilic acid with formamide, an almost quantitative yield of quinazoline-4-oh was obtained. Optimal reaction conditions were established: temperature 130-140 °C, duration 2 hours. Quinazoline-4-oh hydrochloride was obtained from quinazoline-4-oh by passing hydrogen chloride with 96% yield. These compounds at a dose of 100-150 mg/kg exhibit 92% anthelmintic activity against fascioles common in cattle, sheep and goats.
Keywords
Formamide
quinazoline-4-one
quinazoline-4-oh hydrochloride fascioliasis
stability of the drug
medamine
albendazole
cattle
sheep and goats
activity against fascioliasis.
Authors
Saitkulov Foziljon Ergashevich, Elmuradov Burkhon Zhuraevich, Sapaev Bayramdurdi
Rubric:Chemistry
220
4
Share
220
4
References:
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