Unmasking Genetic Vulnerabilities in Breast Cancer Through SNP Analysis
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Jiayi Zhu
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Breast cancer is a prevalent and severe malignancy with significant morbidity and mortality rates worldwide. This investigation sought to elucidate the relationship between single nucleotide polymorphisms (SNPs) and breast cancer. Genome-wide sequencing data from the Sequence Read Archive were harnessed, and comprehensive pipelines were developed to align sequences against chromosome 10 in a cohort of individuals with a history of breast cancer. The study found that while the PTEN gene exhibited just a single unique SNP, suggesting its genetic resilience, other genes presented with a notably higher number of SNPs. Specifically, genes without a defined function harbored the most significant number of unique SNPs. Prior research has underscored its role as a tumor suppressor and its critical association with various malignancies, including breast cancer. These insights offer a deeper understanding of the genomic intricacies of breast cancer, revealing potential genetic vulnerabilities and emphasizing the significance of particular genes and SNP contributions to the disease.
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Authors
Jiayi Zhu
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