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Uncovering the Genetic Basis of Thyroid Cancer: A Study of Single Nucleotide Polymorphisms (SNPs)


Jiayi Wu

Rubric:Preventive Medicine
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Thyroid cancer remains a significant public health concern, with an estimated 43,720 new cases predicted in 2023, affecting both men and women. Our study aimed to explore the genetic underpinnings of thyroid cancer predisposition by analyzing Single Nucleotide Polymorphisms (SNPs). To do so, we leveraged Genome-Wide Sequencing data from the Sequence Read Archive and developed tailored analysis pipelines using Bowtie 2, a popular alignment tool, to map the sequences onto chromosome 7 and perform variant calling. Our analysis revealed 9 SNPs that were present in over 90% of thyroid cancer patients but not in the normal population. These findings hold promise for the development of new strategies for the early detection and prevention of thyroid cancer





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