An influence of total polysaccharide preparations isolated from plants of the genus Ferula on the state of immune reactions in the body of experimental animals
Authors
Saidkhodjayeva Dilfuza Mirtahirovna, Shakhmurova Gulnara Abdullayevna, Rakhmanberdiyeva Rano Karimovna, Syrov Vladimir Nikolayevich
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The total extractive preparations of polysaccharides isolated from Ferula kuhistanica and F. tenuisecta, widely distributed in the Central Asian region, when administered to mice once (per os, 250 mg/kg) with simultaneous immunization of animals with ram erythrocytes, have a pronounced activating effect on the process of primary antibody formation, increasing in the spleen, the number of antibody-forming cells. At the same time, an increase in the cellularity of the central and peripheral organs of immunity was also observed, and the content of erythrocytes and leukocytes increased in the blood. Both studied polysaccharide preparations slightly stimulated changes in the delayed-type hypersensitivity reaction, increased the number of phagocytic peritoneal macrophages, increasing their absorption activity.
The polysaccharide preparation from F.kuhistanica in its effect on the immune reactivity of the organism was superior to the effect of the polysaccharide preparation from F. tenuisecta, as well as the corresponding effect of the reference preparations: immunal and plantaglucid. The polysaccharide preparation from F.tenuisecta had a similar effect to immunal and outperformed the effect of plactaglucid.
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Authors
Saidkhodjayeva Dilfuza Mirtahirovna, Shakhmurova Gulnara Abdullayevna, Rakhmanberdiyeva Rano Karimovna, Syrov Vladimir Nikolayevich
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