Role of local immune system in breast cancer
Authors
Tillyashaykhov Mirzagalib
Share
Annotation
Objective: to study the correlation between the expression of tumor microenvironment receptors and molecular biological subtypes of breast cancer, as well as their effect on prognosis. Materials and methods. To improve the diagnosis and treatment of breast cancer by studying the tumor microenvironment, its impact on the course and prognosis, we analyzed a group of 457 breast cancer patients. Results. PD-1, PD-L1, EGFR and CK 5/6 in luminal tumors had lower values than in triple-negative forms of breast cancer. In luminal type A - PD-1=30%, PD-L 1 - 17.7%, EGFR - 5.9%, and CK 5/6-3.3%, whereas in triple-negative cancers, these indicators were 61.7%, 39.8%, and 53.4%, respectively. Conclusion. Data analysis showed that there is a strong correlation between the expression of the above markers and molecular biological subtypes of breast cancer.
Keywords
Authors
Tillyashaykhov Mirzagalib
Share
References:
1. Choi S. D., Atakhanova N. E., Shayusupov N. R., Iskhakov D. M., Kakhkharov A. Zh. Clinical-morphological and molecular-genetic factors of breast cancer relapse prognosis / / Surgery of Uzbekistan. Tashkent, 2018, no. 2, pp. 43-47.
2. Tillyashaykhov M. N. [Organization of the oncological service of Uzbekistan at the present stage and prospects for further development]. -2017. - No. 1. - pp. 5-7.
3. Hu W, Li X, Zhang C, Yang Y, Jiang J, Wu C. Tumor-associated macrophages in cancers // Clin Transl Oncol. – 2015. – P. 1-8.
4. Marsh T., Pietras K., McAllister S.S. Fibroblasts as architects of cancer pathogenesis // Biochim Biophys Acta. – 2013. – Vol. 1832, №7. – P. 1070-1078.
5. Vangangelt K., van Pelt G., Engels C., et al. Prognostic value of tumor-stroma ratio combined with the immune status of tumors in invasive breast carcinoma // Breast Cancer Res Treat. – 2017. – Vol. 168, №3. – P. 601-612.