Molecular genetic features of vulva squamous cell carcinoma depending on HPV status
Authors
Polatova Djamila, Navruzova Visola
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The study included materials from 76 operations (110 paraffin blocks), which did not undergo neoadjuvant treatment methods, since preoperative exposure to tumors could significantly affect the results of the study, which is why these samples were not included in the study. It was found that a high viral load of HPV in VC correlates with the presence of metastases in the lymph nodes, invasion of the stroma, the degree of differentiation, and lymphovascular invasion, while it is not associated with the stage of the disease. Expression of PD-L1 receptors was more frequently observed in HPV negative VC patients compared to HPV positive ones (7.8 vs 3.7 p=0.03), while STK11 mutation was more common in HPV positive patients. At the same time, the PIK3CA E545 mutation occurred with the same frequency between the two groups of VC patients
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Authors
Polatova Djamila, Navruzova Visola
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