TUMOR MICROENVIRONMENT AND BREAST CANCER FORECAST
Authors
Tillyashaykhov Mirzagalib, Kaxarov Alisher
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Goal: to study the effect of the tumor microenvironment on the course and outcome of breast cancer.
Material and methods. To improve the diagnosis and treatment of breast cancer by studying the tumor microenvironment, its impact on the course and prognosis, we analyzed a group of 457 breast cancer patients.
Results. High LVI was detected in the group of patients with an unfavorable outcome (76.8%), in the group with a favorable outcome, lymphovascular invasion was diagnosed in 33.8% of cases. Tumor infiltration by lymphocytes was diagnosed in 229 patients (50.1%), of which in the group of patients with a favorable outcome of the disease, this sign was detected in 61.6%, with an unfavorable outcome in 38.4% of cases (χ2=7,49, p <0.001).
Conclusion. Thus, in breast cancer, the presence, severity, and cellular components of lymphocytic infiltration in combination with IHC status and molecular genetic markers play an important role in determining the prognosis of the tumor process. Also, this factor is an indicator of the likely positive effect of immunotherapy.
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Authors
Tillyashaykhov Mirzagalib, Kaxarov Alisher
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References:
- Choi S. D., Atakhanova N. E., Shay'usupov N. R., Iskhakov D. M., Kakhkharov A. Zh. Clinical-morphological and molecular-genetic factors of breast cancer relapse prognosis / / Surgery of Uzbekistan. Tashkent, 2018, no. 2, pp. 43-47.
- Tillyashaykhov M. N. [Organization of the oncological service of Uzbekistan at the present stage and prospects for further development]. -2017. - No. 1. - pp. 5-7.
- Hu W, Li X, Zhang C, Yang Y, Jiang J, Wu C. Tumor-associated macrophages in cancers // Clin Transl Oncol. – 2015. – . 1-8.
- Marsh T., Pietras K., McAllister S.S. Fibroblasts as architects of cancer pathogenesis // Biochim Biophys Acta. – 2013. – Vol. 1832, №7. – P. 1070-1078.
- Vangangelt K., van Pelt G., Engels C., et al. Prognostic value of tumor-stroma ratio combined with the immune status of tumors in invasive breast carcinoma // Breast Cancer Res Treat. – 2017. – Vol. 168, №3. – P. 601-612.
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