CHARACTERISTICS OF THE IMMUNOLOGICAL PROPERTIES OF THE EFFECT OF ACUTE EXPOSURE ON THE ORGANISM OF EXPERIMENTAL ANIMALS
Authors
Tukhtaeva H.Kh.

Share
Annotation
The aim of the study was to determine the effect of acute irradiation on the immune status of experimental animals, taking into account the degree of influence of biocorrection on this process. It was found that in white outbred male rats that received and did not receive acute irradiation, distinctive results were obtained in the relative values of immune system cells. This was observed in the total number of lymphocytes, cells - CD3+-, CD4+- and CD8+. A key indicator of the development of secondary immunodeficiency is a decrease in IRI by 2.01 times in the main group. No changes were found in CD20+ cells, in the main group of laboratory animals the number of CD16+ cells increased by 1.35 times, and in CD95+ cells it decreased by 1.51 times. The deficiency of the immune system in the biocorrection group was relatively shallow, the biological product used had an immunostimulating effect. It has been proven that its use reduced the negative impact of acute irradiation on the quantitative indicators of immune system cells.
Keywords
Authors
Tukhtaeva H.Kh.

Share
References:
1.Allanazarov A.Kh. Tazhribada gene-modificationlangan mahsulotlarning immuno tizimi kўrsatkichlariga tasirini qiyosiy baholash usuli // Uslubiy tavsiyanom. - Bukhoro, 2021. - 23 b.
2. Zharmukhamedova T.Yu., Semushina S.G., Pakhomova I.A., Pimenov M.S., Murashov A.N. International rules for working with laboratory animals during preclinical testing // Toxicological Bulletin. - Moscow, 2011. - No. 4 (109). - P.2-9.
3. Konoplyannikov A.G. Cellular bases of human radiation effects // In the book: “Radiation Medicine. Volume 1. Theoretical Foundations of Radiation Medicine. Under total ed. L.A. Ilyin. - Moscow: Ed. AT, 2004. - S.189-277.
4. Mikheev A.N. Small doses of radiobiology. My little radiological faith. - Kyiv, Photosocial Center, 2016. - 371 p.
5. Nikolaeva A.A. Comparative analysis of the radioprotective properties of bee venom in relation to the blood system of rats // Bulletin of the Nizhny Novgorod University named after N.I. Lobachevsky. - 2011. - No. 6 (1). - P.149-153.
6. Nuraliev N.A., Bektimirov A.M-T., Alimova M.T., Suvonov K.Zh. Rules and methods of work with laboratory animals in experimental microbiological and immunological studies // Methodological guide. - Tashkent, 2016. - 34 p.
7. Polevshchikov A.V. Unsolved problems of modern immunology. Molecular and cellular bases of immunoregulation, immunodiagnostics and immunocorrection (experimental models) // Medical Immunology. - 2009. - Volume 11, No. 4-5. - P.330-331.
8. Terentiev A.A., Poryadin G.V., Salmasi Zh.M., Alexandrova I.A., Tagirova A.K., Moldogazieva N.T., Kazimirsky A.N. Increased apoptosis of CD95+-lymphocytes under the influence of a synthetic peptide from human alpha-fetoprotein (AFP14-20) // Modern science-intensive technologies. - 2005. - No. 10. - P. 66-68;Barabanova A., Baranov A., Bushmanov A., Guskova A. Radiation Effects in Man Selected clinical lectures. Eds.: K. Kotenko, A. Bushmanov. – М.: ОАО «Издательство «Медицина», 2008. - 158 с.
9.Ron E., Jacob P. Late health effects of ionizing radiation: bridging the experimental and epidemiologic divide // Radiat. Res. - 2010. - V. 174, №6. - Р.789-792.
10.Kreuzer M., Auvinen A., Cardis E. Low dose ionizing radiation and cardiovascular diseases – Strategies for molecular epidemiological studies in Europe // Mutat. Res. - 2015. - V. 764. - P. 90-100.