MOLECULAR MECHANISMS OF AGING IN THYROID CELLS
Authors
Kadyrova Dilbar Abdullaevna, Mirkhamidova Parida, Shakhmurova Gulnara Abdullaevna, Ziyamukhamedova Sabohat Abdullaevna
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this paper presents the molecular mechanisms of aging in thyroid cells of elderly people and the causes of disturbances in the regulation of thyroglobulin gene expression. It was found that during aging, there is a disturbance in the regulation of thyroglobulin gene expression at the transcription level. A direct correlation was found between the degree of thyroglobulin gene expression in thyroid cells during cellular aging and DNase I - nuclear chromatin hypersensitivity.
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Authors
Kadyrova Dilbar Abdullaevna, Mirkhamidova Parida, Shakhmurova Gulnara Abdullaevna, Ziyamukhamedova Sabohat Abdullaevna
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References:
1. Anisimov V.N. Relationship between aging and cancer: physiological and molecular mechanisms// Advances in Gerontology -1999.-V.4.-P.34-44.
2. De Vijlder J.J.M. Carber B. Individual thyroglobulin polyribosomes at tumors of a thyroid gland // J.Clin. Endocrin.- 1999.- V.104.- P.2448-2452.
3. Dashkevich V.S., Arshinova T.V. Isolation of fractions of replicating DNA from rat liver by detergent-free phenol method // Biology. - 1963. - Issue. 43, v. 15. - P. 133-136.
4. Wei J.Y. The analysis of synthesis of protein in cells and occurrence of age diseases. Experiment. Cell.Research.-2005.-v.188.-P.277-284.
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