STUDY OF COLLAGEN STRUCTURE AND TISSUE REACTION DURING IMPLANTATION
Authors
Radjabov Otabek Iskandarovich, Yariev Olimjon Oltinovich, Azimova Luiza Bakhtiyarovna, Filatova Albina Vasilievna, Djurabaev Djalol Turgunbaevich
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Annotation
This paper discusses the method of obtaining and studying collagen isolated from cattle skin using alkaline-salt hydrolysis. The physicochemical properties of collagen, its structure and biocompatibility were studied. The use of IR spectroscopy and SEM made it possible to confirm the preservation of the fibrillar structure of collagen after processing, which is important for its use in medicine. Morphological histological studies on male Wistar rats showed that collagen stimulates metabolic processes and promotes an increase in the number of fibroblasts and collagen fibers, indicating its active participation in tissue restoration. The results showed that collagen has high biocompatibility and is promising for use in medicine.
Keywords
Authors
Radjabov Otabek Iskandarovich, Yariev Olimjon Oltinovich, Azimova Luiza Bakhtiyarovna, Filatova Albina Vasilievna, Djurabaev Djalol Turgunbaevich
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References:
collagen, fibrils, IR spectroscopy, SEM, morphohistology, biocompatibility.
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