DYSREGULATION OF ALTERNATIVE SPLICING IS INVOLVED IN MAJOR DEPRESSIVE DISORDER
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Wenqiao Yu
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Major Depressive Disorder (MDD) is a mental disorder caused by brain malfunction. It’s one of the most common mental disorder, effecting over 7% of the population. Most studies agree that MDD is most likely caused by many different factors, some genetic and some environmental, instead of one specific single nucleotide polymorphism (SNP). This study collected numerous SNPs related to MDD and looked at the function of these genes. We selected the most significant one, alternative splicing for further analysis. By taking a closer look at the three genes that are directly involved in alternative splicing, which are CELF4, RSRC1, and RBFOX1, we were able to understand how it effect the brain. The gene RSRC1 increased the gene expression in the brain and nerves. Data from other studies also showed that CELF4 and RBFOX1 and decrease the gene expression level in other organs. To sum those data up, the dysregulation of alternative splicing can cause the gene expression in different organs to alter in a way that increase the risk of MDD. The systematic abnormity of the alternative splicing process plays an essential role in MDD. Using this study, scientist will be able to better understand how alternative splicing can contribute to MDD and some genes associated with this process.
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Authors
Wenqiao Yu
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References:
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