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Identification of New Differential Expressed Genes of Esophageal Cancer
Authors
Liangtao Song
Rubric:General Biology
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Esophageal cancer (ESCA) is a type of gastrointestinal malignancy. It has one of the lowest survival rates among all types of cancer. Exploring ESCA related genes can help reveal the mechanism of ESCA occurrence and development and develop new diagnostic biomarkers and therapeutic targets. In the current study, three genes including ADCY3, CAB39L and TCOF1 were identified by bioinformatics analysis to show differential expression in ESCA and the adjacent normal tissues. Among the three genes, ADCY3 and TCOF1 were up-regulated, whereas CAB39L was down-regulated in the cancerous tissues. Survival analysis suggests that the expression levels of these genes have no impact on overall survival when analyzed individually. However, in combination analysis, patients with low expression of ADCY3 but high expression of TCOF1 show severe adverse outcomes with the lowest survival level. Therefore, the result suggests the combination of these genes could act as biomarkers for prognostic evaluation.
Keywords
Esophageal cancer
ADCY3
CAB39L
TCOF1
differential expression.
Authors
Liangtao Song
Rubric:General Biology
269
0
Share
269
0
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