Mg–Al LAYERED DOUBLE HYDROXIDE NANOPARTICLE-LOADED POLYMERIC MICRONEEDLES FOR ENHANCED DRUG LOADING CAPACITY
Authors
Javohir Abdusalomov, Mukhriddin Suyundikov, Shavkatjon Azizov, Mirkomil Sharipov, Abbaskhan Turayev
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Layered double hydroxides (LDHs) have emerged as promising nanocarriers for drug delivery due to their high loading capacity and biocompatibility. In this study, Mg–Al LDH nanoparticles were successfully synthesized and utilized as drug carriers for doxorubicin (DOX) loading. The drug-loaded LDH nanoparticles were subsequently incorporated into polyvinyl alcohol (PVA)-based polymeric microneedles to enhance drug loading performance. The encapsulation efficiency and drug loading capacity of the LDH nanoparticles were determined to be 87.3 ± 0.46% and 43.6 ± 0.23%, respectively, indicating a high affinity between doxorubicin and the LDH structure. The incorporation of LDH nanoparticles into the microneedle matrix resulted in a uniform and stable composite system suitable for transdermal applications. Overall, the developed Mg–Al LDH nanoparticle-loaded PVA microneedles demonstrate significant potential as an efficient platform for high-capacity drug loading. This system provides a promising approach for improving the performance of polymeric microneedle-based drug delivery systems.
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Authors
Javohir Abdusalomov, Mukhriddin Suyundikov, Shavkatjon Azizov, Mirkomil Sharipov, Abbaskhan Turayev
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