Biological activities of the product obtained from the reaction of 2-chloro-N-(pyridin-2-yl)acetamide with 5-fluorouracil
Authors
Shirin Azimboyeva, Burieva Dilnoza Madarttovna, Yusufov Mukhriddin Saidovich, Bobonazarova Sarvinoz Habibullaevna, Abdushukurov Anvar Kabirovich
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The chloroacetylation reaction of 2-aminopyridine derivatives was carried out, and the compound synthesized based on the reactions of the obtained chloroacetyl products with 5-fluorouracil was evaluated using the PASS Online program, which predicts the biological activity spectrum of substances based on their structure. When tested against various cancer and normal cell lines, the candidate compound demonstrated high efficacy against leukemia (Kasumi-1) and certain tumors of epithelial origin. At the same time, low activity observed in normal fibroblast cells indicates that the compound possesses selective activity and may potentially exhibit low toxicity. The antibacterial activity of the planned compound was also evaluated, showing the highest activity against Enterococcus faecalis ATCC 29212 and Mycobacterium tuberculosis H37Rv. The drug-like properties and possible adverse effects of the compound were further analyzed using the PASS program.
Keywords
Authors
Shirin Azimboyeva, Burieva Dilnoza Madarttovna, Yusufov Mukhriddin Saidovich, Bobonazarova Sarvinoz Habibullaevna, Abdushukurov Anvar Kabirovich
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