CORRECTION OF METABOLIC AND MORPHOLOGICAL DISORDERS IN EXPERIMENTAL ATHEROCALCINOSIS
Authors
Filatova Albina Vasilievna, Khudaynazarov Sobirjon Khakhramonovich, Vypova Natalia Leonidovna, Shomurotov Shavkat Abduganiyevich, Djurabaev Djalol Turgunbaevich
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This study examined the efficacy of a combination of plant extracts and the reference drug Rosuvastatin Agio in a rabbit model of experimental atherosclerosis. The condition was induced by administering atherogenic substances (cholesterol and vitamin D2) for three months, resulting in severe hypercholesterolemia and pronounced aortic arch atherocalcinosis. The results showed that 30-day use of the plant extract resulted in more pronounced lipid profile normalization than Rosuvastatin: total cholesterol decreased by 89%, and the atherogenicity index decreased from 23.0 to 2.7. Histological analysis confirmed the therapeutic efficacy, manifested in the regression of calcification foci and restoration of the structural order of vascular wall layers. Both therapies promoted normalization of blood glucose levels. These data demonstrate the high hypolipidemic and antiatherosclerotic potential of the studied extract.
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Authors
Filatova Albina Vasilievna, Khudaynazarov Sobirjon Khakhramonovich, Vypova Natalia Leonidovna, Shomurotov Shavkat Abduganiyevich, Djurabaev Djalol Turgunbaevich
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