PROGNOSTIC SIGNIFICANCE OF EGFR AND VEGF RECEPTORS IN COLORECTAL CANCER RECURRENCE PREDICTION
Authors
Tillyashaykhov Mirzagaleb Nigmatovich, Karakhodjaev Botir Shokirovich
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The aim of this study was to evaluate the role of growth factor receptors EGFR and VEGF in predicting recurrence of colorectal cancer. The analysis included 103 tissue samples from patients treated at an oncology center between 2016 and 2022. Immunohistochemical methods were used to assess the expression of EGFR and VEGF, and their association with recurrence or non-recurrence was analyzed. The results demonstrated that positive receptor status was significantly associated with an increased likelihood of recurrence (p=0,018 for EGFR and p=0,001 for VEGF). Odds ratio analysis confirmed that negative status of these markers reduces the risk of recurrence. The findings suggest that EGFR and VEGF have high prognostic value and potential as therapeutic targets in personalized treatment of colorectal cancer. The article emphasizes the need for further research to confirm and expand the application of these biomarkers in clinical practice.
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Authors
Tillyashaykhov Mirzagaleb Nigmatovich, Karakhodjaev Botir Shokirovich
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References:
1. Ferlay J, et al. Global cancer statistics 2019: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2019.
2. Van Cutsem E, et al. Updates on colon and rectal cancer treatment in 2020: a decade in review. Lancet Oncol. 2020.
3. Menter DG, et al. Targeting pathways of resistance to antiangiogenic therapy in colorectal cancer: a focus on VEGF and EGFR. Am J Clin Oncol. 2019.
4. Morgillo F, et al. Mechanisms of resistance to EGFR-targeted drugs: lung cancer and other solid tumors. Crit Rev Oncol Hematol. 2017.
5. Yonesaka K, et al. The role of EGFR mutation and ALK gene rearrangement in lung cancer. Exp Biol Med (Maywood). 2018.
6. Abdollahi A, et al. Regulation of angiogenesis by bFGF and VEGF in patients with lung cancer. Clin Canc Res. 2018.
7. Jubb AM, et al. Impact of VEGF on survival in colorectal cancer patients. Ann Oncol. 2020.
8. Miller KD, et al. Cancer treatment and survivorship statistics, 2021. CA Cancer J Clin. 2021.
9. Bensi M, et al. Advances in personalized therapy in colorectal cancer: focus on targeted therapy. J Clin Med. 2022.
10. Gray R, et al. Treatment of metastatic colorectal cancer with anti-EGFR therapy and KRAS mutation status. J Clin Oncol. 2021.
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