INVESTIGATION OF THE HEPATOPROTECTIVE EFFECT OF ANACARDIUM IN CARBON TETRACHLORIDE- AND ETHANOL-INDUCED HEPATITIS MODELS
Authors
Umarova Gulbakhor, Mukhammadjonova Guzal, Kuziev Sherali, Yunusova Muslima, Dadakhonova Mukhlisa
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Toxic liver injury is among the most common etiological factors of hepatobiliary pathology and is strongly associated with the increasing impact of hepatotoxic xenobiotics from household, industrial, and agricultural chemicals. These exogenous agents not only possess specific mechanisms of action but also trigger universal endogenous damage in hepatocytes through oxidative stress. In this context, polyphenolic compounds with antioxidant properties are considered promising hepatoprotective agents. The present study investigates the hepatoprotective potential of anacardic polyphenol in experimental models of carbon tetrachloride- and ethanol-induced toxic liver injury in Wistar rats. Different doses of the compound were administered orally and intraperitoneally, and its influence on biochemical markers such as total protein, ALT activity, lipid peroxidation products (diene conjugates and MDA), as well as functional indicators (hexobarbital-induced sleep duration) were evaluated. The findings demonstrated that anacardic polyphenol significantly reduced biochemical alterations, restored hepatocellular integrity, and exhibited dose-dependent hepatoprotective activity, with the most effective results observed at 100 mg/kg orally and 5 mg/kg intraperitoneally. These results suggest that anacardic polyphenol may serve as a promising hepatoprotective agent, potentially comparable to established drugs such as Karsil.
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Authors
Umarova Gulbakhor, Mukhammadjonova Guzal, Kuziev Sherali, Yunusova Muslima, Dadakhonova Mukhlisa
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References:
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