Predictive Role of CD4+ T-Lymphocytes in Treatment Response of Soft Tissue Sarcomas
Authors
Polatova Jamila Shagayratovna, Karimova Nargiza Mansurovna, Kahharov Alisher Jamoliddinovich
Share
Annotation
This study highlights the particular importance of CD4 T-lymphocyte levels in the immune microenvironment of soft tissue sarcomas. Data analysis shows that high levels of active CD4+ T-lymphocytes inside the tumor are associated with more favorable morphological responses to therapy, as well as improved clinical outcomes. CD4 levels serve as a promising prognostic marker and can contribute to more accurate prediction of the results of complex treatment, including immunotherapy. The obtained results emphasize the need for expanded research to develop new individualized strategies to enhance the immune response and improve the effectiveness of soft tissue sarcoma therapy.
Keywords
Authors
Polatova Jamila Shagayratovna, Karimova Nargiza Mansurovna, Kahharov Alisher Jamoliddinovich
Share
References:
Huang H, Fan Y, Zhang S, Bai X, Wang X, Shan F. Emerging immunotherapy and tumor microenvironment for advanced sarcoma: a comprehensive review. Front Immunol. 2025 May 21;16:1507870. doi: 10.3389/fimmu.2025.1507870. PMID: 40469285; PMCID: PMC12133756
van der Graaf WTA, Orbach D, Judson IR, Ferrari A. Soft tissue sarcomas in adolescents and young adults: A comparison with their paediatric and adult counterparts. Lancet Oncol. (2017) 18:e166–e75. doi: 10.1016/s1470-2045(17)30099-2
Lee AQ, Hao C, Pan M, Ganjoo KN, Bui N. Use of histologic and immunologic factors in sarcoma to predict response rates to immunotherapy. J Clin Oncol. (2024) 42:11569. doi: 10.1200/JCO.2024.42.16_suppl.11569
Wood GE, Meyer C, Petitprez F, D’Angelo SP. Immunotherapy in sarcoma: current data and promising strategies. Am Soc Clin Oncol Educ Book. (2024) 44:e432234. doi: 10.1200/edbk_432234
Recine F, Vanni S, Bongiovanni A, Fausti V, Mercatali L, Miserocchi G, et al. Clinical and translational implications of immunotherapy in sarcomas. Front Immunol. (2024) 15:1378398. doi: 10.3389/fimmu.2024.1378398
Other articles of the issue
