Phytochemical study and evaluation of the in vitro antioxidant activity of the medicinal plant Brugmansia candida Pers. used in the treatment of madness in the SANKURU province (DR Congo).
Authors
Mosango Mbokuyo David, Musafiri Abdallah Ibrahim, Mayele Masasi Blanchard, Djonga Albert, Nyamangombe Lohandjola Gustave
Share
Annotation
The species Brugmansia candida Pers. was introduced in the Sankuru province of the Democratic Republic of Congo (DRC) by Catholic or Protestant missionaries as an ornamental plant. They were mainly interested in its decorative appearance and beautiful multi-colored flowers, which give off a pleasant scent in the evening and at night. B. candida is known for its psychotropic and hallucinogenic properties. In the Sankuru province, it is known as a strong drug that is easier to obtain than local drugs. The objective of this work was therefore to highlight the phytochemical compounds of this plant and to evaluate their antioxidant activity. This phytochemical analysis was carried out following the method described by Harbone (1998). The polyphenolic compounds were assayed by the spectrometric method and the antioxidant activity was determined using the DPPH and ABTS trapping tests. These analyses showed that aqueous extracts of B. candida leaves contain polyphenols, anthocyanins, tannins, leucoanthocyanidins, alkaloids, bound quinones, and saponins, but no flavonoids. On the other hand, in organic extracts of the leaves of this species, steroids, terpenoids, and free quinones were detected. As for the antioxidant activity, the ABTS radical showed interesting IC50 values, namely 38.95 ± 0.15 µg/mL for aqueous extracts and 21.15 ± 0.08 µg/mL for organic extracts. In conclusion, B. candida leaves are a source of active compounds and have a significant antiradical profile. It can therefore be suggested that this species be integrated into alternative medicine for the management of certain psychosomatic diseases. However, its excessive use should be discouraged by government authorities in the same way as tobacco.
Keywords
Authors
Mosango Mbokuyo David, Musafiri Abdallah Ibrahim, Mayele Masasi Blanchard, Djonga Albert, Nyamangombe Lohandjola Gustave
Share
References:
Stevens, P.F. (2012). Site Web de phylogénie des angiospermes.
Retrieved from: http://www.mobot.org/MOBOT/research/APweb/
Bongbeme, M.M. (2015). Phytochemical study of Brugmansia candida leaves. Unpublished M.Sc. Thesis, Fac. Sciences, University of Kinshasa.
Ibrahim S., Novita D.A., Efdi, M. (2017). Isolation and characterization of Alkaloids from leaves of Brugmansia candida. Journal of Chemical and Pharmaceutical Research, 9(6): 290-293.
Niedz, R.P., Evens T.J., Hyndman S.E., Adkins S., Chellemi, D.O. (2012). In vitro shoot growth of Brugmansia candida Pers. Physiol. Mol. Biol. Plants (1): 69-78
Alvarez, LM, (2008). [English title not available]. (Borrachero, Cacao Sabanero o Floripondio (Brugmansia spp.) Un Grupo de Plantas por Redescubrir en la Biodiversidad Latino americana.) Cultura y Droga, 13(15):77-93. Retrieved from: http://200.21.104.25/culturaydroga/downloads/culturaydroga13%2815%29_6.pdf
Anthony S.J., Zuchowski W., Setzer, W.N. (2009). Composition of the Floral Essential Oil of Brugmansia suaveolens. Rec. Nat. Prod., 3 (2): 76-81.
Gonzalo, J.D. (2015). Toxicose par les végétaux
Odavia, D,.( 2015). Analyse chimique des Brugmansia, Université d’Alexandrie, , Egypte
Mbadiko, CM., Koto-te-Nyiwa, N., Mpiana, PT., Ngombe, NK., Kapepula, PM., Kemfine, LL., Bongo, GN., Mbemba T. (2019). Antioxidant Potential and Anti-Sickling Activity of Different Organs of Curcuma longa. Correlation of the Antioxidant Capacity on Anti-Sickling Activity. South Asian Research Journal of Natural Products, (2): 1-16.
Mbemba, T.F., Mutwale Kapepula ,P., Nzundu Mbo, J.P, Mboloko Esimo, J., Ngombe, N.K., . Kabamba, L.N. (2023). Congolese Traditional Foods as Sources of Antioxidant Nutrients for Disease Prevention. IntechOpen. doi: 10.5772/intechopen.109319
Nyamangombe, G., Mayele, B., Nzembo, F., Nzundu J-P., Amogu J-J. (2023). Evaluation of the toxicity of aqueous extract of Ganoderma applanatum mushroom. Mor. J. Sci. 4 (4): 177-184. Retrieved from https://doi.org/10.5281/zonodo.10426349
Mayele, B. M., Mbandiko, C. M., Ngombe, N. K., Ngbolua, K. N., Mbemba, T F. (2024). Antioxidant and hypoglycemic activities of Curcuma longa L. rhizome harvested from the plateau of Bateke. Orapuh journal 5 (1) : e.1104.
Gonzalo (2015). Toxicose par les alcaloïdes végétaux chez l’homme et l’animal en Colombie. Toxines (Bâle) 7(12) : 5408-5416. DOI :10.3390/toxins7124892. PMID : 26690479. PMCID : PMC4690142.
Floegel, K.C, Kim, D-O., Chung, S-J., Koo, S., Chun ,O-K. (2011). Comparison of ABTS /DPPH assays to measure antioxidant capacity in popular antioxidant-rich. Journal of food composition and analysis, 24 (7): 1043-1048.
Petricevich, V.L., Salinas-Sanchez, D. O., Avilés-Montes ,D., César Sotelo-Leyva, C., Abarca-Varga, R. (2020). Chemical compounds, Pharmacological and Toxical activity of Brugmansia suaveolens: A revue. VL 9. Retrieved from https://doi.org/10.3390/plants9091161
Algradi, A. M., Liu, Y., Yang, B-Y., Kuang, H-X. (2021). Revue on the genus Brugmansia: Traditional usage, phytochemistry, pharmacology and toxicity. Journal of Ethnopharmacology 279. DOI: 101016/j.jep.2021.113910.
Pundira, S., Kumar Shuklab, M.K., Sing, A., Chauhana, R., Lala, U.R., Aalia, A., Kumarb, D. (2022). A comprehensive review on angel’s trumpet (Brugmansia suaveolens). South African Journal of Botany 151: 256-266.
Other articles of the issue
