DETERMINATION OF THE EFFECTIVE DOSE OF "SUMAKH FRUIT EXTRACT" IN THE PROCESS OF ARTIFICIAL MUTATION CREATED USING 4-NITROQUINOLINE-1-OXIDE.
Authors
Guliyev Mahir, İsrafilova Sabina, Yildirim Leyla, Sadiqi İlaha
Share
Annotation
The study evaluated the antimutagenic efficacy of sumakh fruit extract in artificial mutagenesis caused by 4-nitroquinoline-1-oxide (4NQO). The extract was tested on peripheral blood lymphocytes of healthy donors exposed to 4NQO after administration of various doses of the extract. The frequency of chromosomal aberrations in metaphase cells was used to assess antimutagenic activity.
The results showed that the extract reduces the frequency of chromosomal changes in doses from 0.001 to 1.0 mcg/ml, with the greatest effectiveness at 0.01 mcg/ml. Thus, sumakh fruit extract has demonstrated potential as an antimutagenic agent protecting the genome from damage
Keywords
Authors
Guliyev Mahir, İsrafilova Sabina, Yildirim Leyla, Sadiqi İlaha
Share
References:
Current Trends and Future Perspectives of Antimutagenic Agents // Journal of Food Chemistry&Nanotechnology. URL: http://dx.doi.org/10.17756/jfcn.2016–01
Muhammad Akram, Muhammad Riaz, Abdul Wadood Chishti Wadood, Ali Hazrat et. all. Medicinal plants with anti-mutagenic potential // Biotechnology & Biotechnological Equipment, – 34:1. – P. 309–318. DOI: 10.1080/13102818.2020.1749527
Muhammad Mushtaq, Bushra Sultana, Farooq Anwar, Sidra Batool. Antimutagenic and Antioxidant po- tential of aqueous and acidified methanol extracts from citrus limonum fruit residues // J. Chil. Chem. Soc., – No. 2. 2015.
Wang LE, Hsu TC, Xiong P, Strom SS, Duvic M, Clayman GL, et al. 4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of nonmelanoma skin cancer: a case–control analysis. J Invest Dermatol. 2007;127:196–205.
Other articles of the issue
