Закажите звонок

Отправить
×

Спасибо!

Ваша заявка успешно отправлена. В ближайшее время с Вами свяжется наш специалист.
×

List of publications for

×

European Science Review, Issue 1-2/2017

Genetic determinancy with polymorphism of gene ACE of the risk for development of chronic kidney disease in children and adolescents with type 1 diabetes mellitus of Uzbek population

DOI: https://doi.org/10.29013/ESR-17-1.2-104-108

Pages: 104 - 108

Authors: Rakhimova G. N., Sadikova A. S.

Abstract: The purpose of research was to study distribution of the alleles frequencies and genotypes of I/D gene-candidate of the kidney pathology AKF in children and adolescents with type I diabetes mellitus in Uzbek population with presence and absence of CKD (chronic kidney diseases), and to assess informative capacity of its study as marker for prognosis of kidney 105 Genetic determinancy with polymorphism of gene ACE of the risk for development of chronic kidney disease in children... lesion in diabetes mellitus type 1.There were studied 120 children and adolescents with type 1 diabetes mellitus, of them males were 53 (44,2%) and females — 67 (55,8%). The mean age of patients was 13,8±2,7 years (Me 15,0; IQR 13,0–16,0). The stages of chronic kidney diseases were classified according to recommendations K/DOQI (2012). There was found that in children and adolescents with DM type 1 in Uzbek population the use of new classification K/DOQI (2012) allowed evaluation of the attenuation of the kidney function at earlier stages: in 61,9% of children and adolescents with DM type 1 even still at stage NAU there was noted SKD 80,6±7,5 ml/min/1,73 m 2, that corresponds stage II of CKD and 16,7% have CKD 45±9,5 ml/min/1,73 m2, that corresponds to stage III CKD. As well as in 28,6% of children and adolescents at the stage MAU there is noted CKD II, in 75.0% of CKD III stage, respectively. With regard to frequency the distribution of genotypes of ACE gene in children and adolescents with type I diabetes mellitus was characterized by reliable correlation of the DD genotype connected to stage of severity of CKD, reduction of ECV, that confirms effect of genetic factors in the development of CKD. I/D polymorphism of ACE gene is the molecular-genetic marker of the predisposition to the development of CKD in type I DM in children and adolescents of Uzbek population.

Keywords: diabetes mellitus, children and adolescents, CKD, polymorphism of ACE gene

Bibliography:
1. Vikulova O. K. Clinical-laboratory and genetic factors of development and progressing of diabetic nephropathy in the patients with
type 1 diabetes mellitus: Autoref. Diss. … cand.med.sci. – Moscow; – 2003.
2. Zablitsev S. V., Chernobrivtsev P. A., Kishenya M. S., Pischulina S. V. Role of genetic marker of endothelial dysfunction of gene ACE in
the pathogenesis of glomerulonephritis. Tavricheskiy medico-biological vestnik, – 2012. – Vol. 15, – No. 3. – 105–108.
3. Ivanova I. E., Rodionov V. A., Semenova L. V. Chronic kidney disease in children of Chuvashckaya Republic. Pediatric, – 2011, – Vol.
90, – No. 3. – 138–144.
4. Maslova O. V., Cuntsov Yu. I., Shestakova M. V., Kazakov I. V., Bikulova O. K., Cukhareva O.Yu. et al. Prevalence of kidney lesion in
diabetes mellitus of type 1 and type 2 in the Russian Federation. Diabetes Mellitus. – 2009. – No. 4. – 47–51.
5. Rakhimova G. N., Sadikova A. S. Clinical-genetic risk factors for development of chronic renal insufficiency in children and adolescents
with type 1 DM of Uzbek population. Theoretical and Clinical medicine, – 2014. – 124–128.
6. Shestakova M. V., Dedov I. I. Diabetes mellitus and chronic kidney disease. – Moscow, – 2009.
7. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International Supplements.
– 2013; – 3 (1):1–150. Available from: http://www. kdigo.org/clinical_practice_guidelines/pdf/CKD/KDIG0_2012_KD_
GL.pdf.
8. Fogarty D. G., Rich S. S., Hanna L., Warram J. H., Krolewski A. S. Urinary albumin excretion in families with type 2 diabetes is heritable
and genetically correlated to blood pressure. Kidney Int. – 2000. – 57 (1): 250–257. – doi: 10.1046/j.1523–1755.2000.00833.x
9. Seaquist E. R., Goetz F. C., Rich S., Barbosa J. Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic
nephropathy. N Engl J Med. – 1989. – 320 (18):1161–1165.
Section 8. Medical science
108
10. Ng D. P., Tai B. C., Koh D., Tan K. W., Chia K. S. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association
with diabetic nephropathy: a meta-analysis of studies reported between – 1994 and – 2004 and comprising 14,727 subjects. Diabetologia.
– 2005; 48 (5):1008–1016. – doi: 10.1007/s00125–005–1726–2
11. Shestakova M. V., Vikulova O. K., Gorashko N. M., Voronko O. E., Babunova N. B., Nosikov V. V., et al. The relationship between genetic
and haemodynamic factors in diabetic nephropathy (DN): Case-control study in type 1 diabetes mellitus (T1DM). Diabetes Res Clin
Pract. – 2006. – 74 (2): – P. 41–50. – doi: 10.1016/j.diabres. – 2006.06.013.
12. Hixson J. E., McMahan C. A., McGill H. C. Jr, Strong J. P. Apo B. insertion/deletion polymorphisms are associated with atherosclerosis
in young black but not young white males. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group.
Arterioscler Thromb. – 1992. – 12 (9):1023–1029. – doi: 10.1161/01. ATV.12.9.1023.