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European Science Review, Issue 1-2/2017

Definition the frequency of gene polymorphism G2014 А ESR-α and its significance in the pathogenesis of osteoporosis

DOI: https://doi.org/10.29013/ESR-17-1.2-10-12

Pages: 10 - 12

Authors: Karimov К. Y., Ibragimov Z. Z., Mukhamedov R. S., Alimov T. R., Boboev K. T.

Abstract: The results of the genetic analysis showed that the frequency of ESR1 gene alleles studied in patients and controls was significantly different. It was revealed that in the basic group the association of polymorphism rs 2228480 ESR1 gene plays an important role in the osteoporosis (OP). The presence of an allele “A” and hetero/homozygous genotypes (G/A and A/A) of this polymorphism significantly increases and carrier allele genotype G and G/G lowers the risk of OP

Keywords: single nucleotide polymorphisms, association, polymorphism rs2228480, ESR1 gene osteoporosis

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