Закажите звонок

Отправить
×

Спасибо!

Ваша заявка успешно отправлена. В ближайшее время с Вами свяжется наш специалист.
×

List of publications for

×

European Science Review, Issue 9-10/2016

Study of relation of polymorphism Gene Glut9 with coronary heart disease associated asymptomatic hyperuricemia in Uzbek population

DOI: https://doi.org/10.29013/ESR-16-9.10-136-138

Pages: 136 - 138

Authors: Tashkenbaeva E. N., Togaev D. K., Ziyadullaev S. K.

Abstract: According to the modern conception ischemic heart disease (IHD) relates to category of multifactorial disease in the development of it both environmental factors and individual genetic predisposition have the important role. In the article it has been presented the analyses of the results of distribution frequencies of alleles and T/G genotypes of the polymorph GLUT9 gene in the population of Uzbek nationality suffered from IHD with asymptomatic hyperuricemia in the comparison with the healthy part of population. It has been established that in the forming of genetic structure of IHD associated with asymptomatic hyperuricemia in Uzbek population genotype GLUT9T/T and allele GLUT9T play the important role.

Keywords: ischemic heart disease, asymptomatic hyperuricemia, genetic polymorphism, Uzbek population

Bibliography:
1. Fang J., Alderman M. N. Serum uric acid and cardiovascular mortality. – The NHANES1 Epidemiologic Follow–up Study, – 1971–
1992//JAMA. – 2000. (283). – 2404–2410.
2. Francesca M. A Genetic Marker of Uric Acid Level, Carotid Atherosclerosis, and Arterial Stiffness: A Family – Based Study//AJKD. –
2014. (1). 1–9.
3. Goya Wannamethee S. Serum Uric Acid Is Not an Independent Risk Factor for Coronary Heart Disease//Current Hypertension
Reports. – 2001 (3). – 190–196.
Sectiom 6. Medical science
138
4. Kullo I., Cooper L. Early identification of cardiovascular risk using genomics and proteomics//Nat. Rev. Cardiol. – 2010. – 7(6).
309–317.
5. Kanellis J, Kang DH. Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol. – 2005; –
25:39–42.
6. Meng Q., Yue J., Shang M. et al. Correlation of GLUT9 Polymorphisms With Gout Risk//Medicine. – 2015. 94. (44). 1–7.
7. Min L. Association of the polymorphisms of SLC2A9 gene with primary gout and uric acid levels in Chinese Han population. North
Sichuan Medical College. – 2009;60:3446.
8. Stark K, Reinhard W, Neureuther K, et al. Association of common polymorphisms in GLUT9 gene with gout but not with coronary
artery disease in a large case-control study. PLoS ONE. – 2008;3: e1948.
9. Swerdlow D., Holmes M., Harrison S. et al. The genetics of coronary heart disease//Br.Med. Bull. – 2012. 102. (1). 59–77.
10. Vitart V, Rudan I, Hayward C, et al. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion
and gout. Nat Genet. – 2008;40:437–442.