Pages: 134 - 135
Authors: Sirozhiddinova K. N., Abdullaeva M. N.
Abstract: The results of examination of 140 newborns with neonatal pathology on CIC contents and three classes of immunoglobulins (A, M, G) in the blood serum have been presented in the article. The highest CIC indices have been noted in the newborns with intrauterine pneumonia (IUP) that makes 143,5 ± 0,87 cond. un. The same CIC indices have been noted in the newborns with neonatal pneumonia (NP) (140,7 ± 0,89 cond. un.) and purulent inflammatory diseases (PID) (136,4 ± 0,83). High CIC indices prove that there is excessive amount of antigens in the newborns body which invaded there in the intrauterine period. Complement concentration (CH50) decreases in adverse proportion to a high CIC level (43,4 un.- IUI, 42,7. un. — NP, 39,6 un. — PID, 49,3 un. in the norm), that can be explained by complement consumption in antigen — antibody reaction in CIC formation. Low indices of Ig G in comparison with the norm in the newborns in neonatal pneumonia (3,9 ± 0,29), purulent inflammatory diseases (3,76 ± 0,3) admit the thought that placental transmission of Ig G and intrauterine infection take place.
Keywords: Circulating immune complexes, complement, immunoglobulins, newborns
1. Abdullaeva M. N. Activity of proteolytic blood systems, eicosanoids, immunological mechanisms and their correction in acute pneumonia
in early age children: Thesis abstract. d.m. s. – Saint – Petersburg, – 1992. – P. – 25.
2. Baranov A. A. Children’s diseases. Text- book. – Moscow, – 2007. – P. 230–236.
3. Haitov R. M. Pinegin B. V. Contemporary ideas of body protection from infections. Immunology. – 2000. – N 1 – P. – 61–64.
4. Shabalov N. P. Neonatology volume II. Text – book. – Moscow, – 2009. – P. 8–50.
5. Shabalov N. P. General biology problem: regularities and consequences of human perinatal infection. Pediatrics/2012/volume 91/N. 3 –
6. Mackay I. R., Water J. V., Gershwin M. E. Autoimmunity: thoughts for the millennium//Clin. Rev. Allergy Immunol. – 2000. – Vol.
18, N 1. – P. 87–117.
7. Nezlin R. A. Quantitative approach to the determination of antigen in immune complexes//J. Immunol. Methods. – 2000. – Vol. 237. –