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European Science Review, Issue 9-10/2016

Influence modulators of nitric oxide synthesis on the activity of liver enzymes monooxygenase in animals with acute toxic hepatits

DOI: https://doi.org/10.29013/ESR-16-9.10-129-133

Pages: 129 - 133

Authors: Sayfullaeva S. A.

Abstract: A nonselective inhibitor L‑NAME NOS (eNOS and nNOS) and selective inhibitor 7‑NI (nNOS) inhibit, and selective inhibitor iNOS- S‑MT, and the donor L‑arginine NO- increase the activity of enzymes of the monooxygenase system of the liver. The inhibition of the activity of microsomal liver enzymes by the action of L‑NAME statistically correlated with indicators of high activity in microsomesiNOS, content of ONO2‑and low activity of eNOS. Under the action of the selective inhibitor iNOS- S‑MT stimulation of functional activity of microsomal enzymes is correlated with the induction of eNOS, iNOS inhibition and the content ONO2-. The lack of correlation between the NO in the microsomes and microsomal enzymes in the liver give the reason to believe that an important factor modulating the activity of monooxygenases are isozymes NOS — eNOS, iNOS and the content of ONO2.

Keywords: pathophysiology, liver pathologies, NO- system with monooxygenase, cytochrome P‑450, endothelial (eNOS), neuronal (nNOS), inducible (iNOS).

Bibliography:
1. The activated oxygen metabolites in the monooksigenanykh Reactions/Lyakhovich V. V., Vavilin V. A., Zenkov N. K., Menshchikova
E. B.//Bulletin. From the Russian Academy of Medical Science. – 2005. – № 4 (118). – P. 7–12.
2. Garbuzenko D. V. Mechanisms of compensation of structure and function of a liver at its damage and their practical value//Ros. zhurn.
gastrojenterol, Hypatolum., kolopraktol. – 2008, – No. 6. – P. 14–21.
3. Hydroxylation of derivants of aniline and an aminoantipirin (1 – phenyl – 2, 3‑dimetil-aminopirazolon‑5) in liver/A. I endoplazmaticheskomretikuluma.
Archakov, I. N. Karuzin, V. N. Tveritapov, I. S. Kokareva//Biochemistry. – 1975. – T. 40, vyp. 1. – P. 29–32.
4. Gilyano N.Ya., L. V. Konevega, Noskin L. A. Dinamika of change of intracellular level of superoxide and NO in endotheliocytes and
cages of a carcinoma of the person after their processing by inhibitors NO sintazy//Bulletin the ex-item biol. and medical – 2010. – T.
149, – P. 85–88.
5. Griglevski R. E. Participation of the free radicals in transformations of an endothelial prostatsiklin and nitric oxide//News of a pharmaceutics
and medical – 1997. – № 1–2. – P. 2–8.
6. The protective and damaging effects of a periodic hypoxia: role of oxide of Nitrogen/Manukhin E. B., Downey H. F., Mallett R. T.,
Malyshev I. Yu.//Vestn. Russian Academy of Medical Science. – 2007. – № 2. – P. 25–33.
7. Zenkov N. K., Menshchikova E. B., Reutov V. P. NO sintazy in norm and at pathology of various genesis//Vestn. Russian Academy of
Medical Science. – 2000. – № 4. – P. 30–34.
8. Nitrogen oxide and peroxide oxidation of lipids as factors of endogenic intoxication at urgent states/Items. Golikov, N. Yu. Nikolaeva,
I. A. Gavrilenko and other//Stalemate. Physical. and the ex-item rubbed. – 2000. – № 2. – P. 6–9.
Influence modulators of nitric oxide synthesis on the activity of liver enzymes monooxygenase in animals with acute toxic hepatits
133
9. Pokrovsk V. I., Vinogradov N. A. Nitrogen oxide, its physiological and pathophysiological properties//Ter. arkh. – 2005. – № 1. – P. 82–87.
10. Ravayeva M. Yu., Chuyan E. N. Changes of activity of synthesis of nitrogen oxide under the influence of low-strong millimetric radiation//
the Biology, Chemistry Series. – 2011. – T. 24 (63), – No. 4. – P. 200–210.
11. Starodubtsev M. N. Peroksinitrit in physiology and pathology of blood cells//M.: “Medicine”. – 2011. – 200 s.
12. Sumbayev V. V., Yasinskaya I. M. Influence of santobane on activity of a sintaza of nitrogen oxide in a liver, lungs and a brain of rats//Sovr.
probl. toksikol. – 2000. – № 3. – P. 3–7.
13. Torkunov P. A., Shabanov P. D. Application of inhibitors NO sintazy, derivants of a L‑arginine, for prevention of the experimental toxic
hypostasis//Eksp. and klin. farmakol. – 2009. – T. 72, No. 2. – P. 44–46.
14. Endotelioprotektorny effects of a L‑arginine at model operation of deficiency of an oxide Nitrogen/Pokrovsky M. V., Pokrovsk T. G.,
Kochkarov V. I., Artyushkova E. B.//Ex-item and klin. farmakol. – 2008. – № 2. – P. 29–31.
15. Alderion W. K., Cooper C. E., Knowles R. G. Nitric oxide synthases: structure, function and inhibition//Biochem J. – 2001. – Vol.
357. – P. 593–615.
16. Bast A., Nordhook J. Product inhibition during the hepatic N‑demethylation of aminopyrine in the rat//Biochem. Pharmacol. – 1981. –
Vol. 30, No. 1. – P. 19–24.
17. Chosh N. C., Kar N. C. Chayeriyee I. Special difference in regard to the distribution of glucose‑6‑phosphatase//Nature. – 1983. –
№ 4. – P. 596–597.
18. Cooke C., Davidge S. Peroxynitrite increases iNostrougt NF-Kappa B and decreases prostacycline synthase in endotheline
cells//Am. J. Cell. Physsiol. –2009. – Vol. 282. – P. 395–402.
19. Dedon P., Tfnnenbaum S. Reaktive nitrogen species in the chemical biology of inflammation//Arch. Biochem. Biophys. – 2004. – Vol.
423. – P. 12–22.
20. Endothelial beta3‑adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endotheliumdependent
hyperpolarization/Dessy C., Moniotte S.//Circulation. – 2004. – N110, – P. 948–954.
21. Guayao W. U., Morris S. M. Arginine metabolism: nitric oxide and beyond//Biochem J. – 1998. – Vol. 336. – P. 1–17.
22. Interaction of nitric oxide and the cytochrome P‑450 system on blood pressure and renal function in the rat: dependence on sodium intake/
Kuczeriszka M., Olszynski K. H.//ActaPhysiologica. – 2011. – Vol. 201. – P. 493–502.
23. Lehnert N., Scheidt R. W. Cytochrome P‑450 Catalyzed Nitric Oxide Synthesis: A Theoretical Study//Inorganic Chem. – 2010. – Vol.
49. – P. 759–768.
24. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors/Mollace V., Muscoli C.,//Pharmacol. Rev. – 2005. –
Vol. 57. – P. 217–252.
25. Nitric oxide and cerebral blood flow responses to hyperbaric oxygen/Demchenko J. T., Boso A. E., O’Nell T. J. et al.//J. Appl. Physiol. –
2000. – Vol. – P. 1381–1389.
26. Okano A., Mouda H., Ohkubo C. Decreased plasma levels of nitric oxide metabolites, angiotensin II and aldosterone in spontaneously
hypertensive rats exposed to 5 mT static magnetic field//Bioelectromagnetics. – 2005. – P. 161–172.
27. Omura T., Sato R. The carbon monoide-binding pigmenr liver microsomes. Evidence for its hemoprotein nature//J. Biol. Chem. –
1964. – Vol. 230, – No. 2. – P. 2370–2378.
28. Protein measurement with the Folin phenol reagent.//O. H. Lowry, N. G. Rosenbrough, N. J. Farr, R. J. Randall//J. Biol. Chem. – Vol. –
193, – N1. – P. 265–275.
29. Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells/Joshi M. S., Ferguson T. B. Jr., Johnson F. K. et
al.//Proc. Natl. Acad. Sci. USA. – 2007. – Vol. 104, – N24. – P. 9982–9987.
30. Repression of phenobarbital-dependent CYP2B1 mRNA induction by reactive oxygen species in primary rat hepatocyte
cultures/K. I. Hirsch-Ernst, K. Schlaefer, D. Bauer et al.//Mol. Pharmacol. – 2001. – Vol. 59. – P. 1402–1409.
31. Scibior D., Creezot A. Arginine – metabolism and functions in the human organism//PostepyHig. Med. Dosw. – 2004. – Vol. 58. – P.
321–332.
32. Stem cell for liver tissue rapair: current knowledge and perspectives/Lysy P. A.,//World J. Gastroenterol. – 2008. – Vol. 14, – N6. –
864–875.
33. Symons A. M., King L. J. Inflammation, reactive oxygen species and cytochrome P‑450//Inflammopharmacology. – 2003. – Vol. 11. –
P. 75–86.
34. Taylor C. T., Moncada S. Nitric oxide, cytochrome C oxidase, and the cellular Responge to Hypoxia//Am. J Heart Association. –
2010. – Vol. 3. – P. 643.
35. Villeneuve J. P., Pichette V. Cytochrome P‑450 and liver diseases//Curr. Drug Metab. – 2004. – Vol. 5. – P. 273–282.
36. Williams C. H., Kamin H. Microsomal triphosphopyridine nucleotide – cytochrome with-reductases of liver//J. Biol. Chem. – Vol.
237, – No. 2. – P. 587–595.
37. Yang C. H., Kicha L. P. A direct fluorometric assay of benzo/a/pyrene – hydroxylase//Analyt. Biochem. – 1978. – Vol. 84. – P. 154–163.
38. Yasui, H., Hayashi S., Sakurai H. Possible involvement of singlet oxygen species as multiple oxidants in P450 catalytic reactions//Drug
Metab. Pharmacokinet. – 2005. – Vol. 20. – P. 1–13.