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List of publications for


European Science Review, Issue 9-10/2016

Insulin resistance in children and teenagers with exogenous constitutive obesity

DOI: https://doi.org/10.29013/ESR-16-9.10-124-127

Pages: 124 - 127

Authors: Rakhimovа G. N., Azimova S. S.

Abstract: The study consisted of 100 children and teenagers with exogenous constitutive obesity (ECO) of Uzbek population aged from 6 to 16. The mean age of the patients was 11,7±0,25 years old. The conducted researches showed that the values Insulin resistance in children and teenagers with exogenous constitutive obesity 125 НОМА>97 percentile occurred more often in boys than in girls at all stages of sexual development. According to our data, the indicators HOMA-IR according to Tanner 1 ≥1,4 and Tanner 2–5 ≥1,8 can be used as criterion for intensive search of components of metabolic syndrome. The level of SHBG in obesity, regardless sex and stage of sexual development, is significantly lower than in the control group; herewith, it is lower in boys than in girls.

Keywords: children, teenagers, obesity, insulin resistance, sex hormone-binding globulin

1. Азимова Ш. Ш., Рахимова Г. Н. Выявление риска развития метаболического синдрома по окружности талии у детей и подростков
узбекской национальности. Патент № DGU 02583 от – 2012 г.
2. Бородина О. В. Оценка инсулинорезистентности у детей и подростков с ожирением//Проблемы эндокринологии. – 2003. –
Т. 49 (6). – С. 8–9.
3. Рахимова Г. Н., Азимова Ш. Ш. Интегральная оценка факторов риска развития МС у детей и подростков с ожирением//МЭЖ. –
2012. – № 3 (43).
4. Araki S., Dobashi K., Kubo K. Prevalence of ‘obesity disease’ and ‘metabolic syndrome’ in obese pediatric outpatients at the University
Hospital of Occupational and Environmental Health, Japan//J UOEH. – 2008. – Vol. 30 (3). – P. 309–319.
5. Choi Y., Choi S., Kim H. et al.A higher burden of small low-density lipoprotein particles is associated with profound changes in the free
androgen index in male adolescents//J Korean Med Sci. – 2011. – Vol.26 (4). – P. 534–539.
6. Jose R., David T., Pietrobelli A., Allison D. Waist Circumference Percentiles in Nationally Representative Samples of African-American,
European-American, and Mexican-American Children and Adolescents//J Pediatr. – 2004. – Vol. 145. – P.43–44.
7. Keskin M., Kurtoglu S., Kendirci M. Homeostasis Model Assessment Is More Reliable Than the Fasting Glucose/Insulin Ratio and
Quantitative Insulin Sensitivity Check Index for Assessing Insulin Resistance Among Obese Children and Adolescents//Pediatrics. –
2005. – Vol. 115. – P. 500–503.
Assessment achievement of target levels of glycemic control in children with type 1 diabetes...
8. Lambert M., Paradis G., O’Loughlin J. Insulin resistance syndrome in a representative sample of children and adolescents from Quebec,
Canada//Int. J. Obes. Relat. Metab. Disord. – 2004. – Vol. 28. – P. 833–841.
9. Moran A., Jacobs D., Steinberger J. et al. Insulin resistance during puberty: results from clamp studies in 357 children//Diabetes. –
1999. – Vol. 48 (10). – P. 2039–2044.
10. Zimmet P., Alberti G., Kaufman F., Tajima N. The metabolic syndrome in children and adolescents-an IDF consensus report//Pediatric
Diabetes. – 2007. – Vol 8. – Р. 299–306