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European Science Review, Issue 9-10/2016

Impact of photodynamic therapy and СО2 laser treatment on the planimetric figures of festering wounds in the experiment

DOI: https://doi.org/10.29013/ESR-16-9.10-112-114

Pages: 112 - 114

Authors: Murodov A. S.

Abstract: Objective: assess the complex action of photodynamic therapy and СО2 laser on planimetric figures purulent wounds in the experiment. Materials and methods. purulent wound model reproduced in 80 male rats by MP Thick (2002) with some modification. Animals from the third day were divided into 4 groups: 1) 20 rats with physiological regeneration, 2) 20 rats with standard therapy, and 3) 20 rats PDT 4) rats 20 inclusion complex treatment with conventional methods, the СО2 laser 3–4 times daily until the wound cleansing from necrotic raids and PDT. Studied plane geometry, healing time, peripheral blood counts and morphology of biopsies from the wound bed and the wall on the 1st, 3rd, 7th and 10th day of the experiment. Results. Photodynamic therapy in a СО2 laser complex was not sufficiently effective invasive treatment of purulent wounds and allows to recommend its use in clinical practice for the treatment of local purulent-destructive diseases of soft tissues. Complex application of PDT and СО2 laser leads to an earlier cleansing from the pus, the active formation of granulation tissue and shortening deadlines complete epithelialization of the wound surface. Conclusions: Complex treatment with СО2 laser and photodynamic therapy is the most effective, as compared to other methods studied separately.

Keywords: purulent wounds, planimetry, laser, photodynamic therapy

Bibliography:
1. Abaev J. K. Surgeon Directory. Wounds and wound infektsiya. – Rostov n/D: Phoenix, – 2006. – with 4–6.
2. Ginyuk V. A. Using phototherapy for the treatment of purulent wounds and the possibility of its use in patients with acute paraproctitis//
Military meditsina. – 2010. – № 3. – S. 79–83.
3. Derbenyov V. A., Azimshoev A. M., Sharifov A. D. Photoditazine in the complex treatment of purulent wounds//Russian biotherapeutic
zhurnal. – 2007. – № 1. – S. 14–16.
4. Kum I. V., Zhmakin A. I., Beetle I. G. Microbiological study the efficacy of photodynamic therapy in colorectal surgery//Medical Journal
BGMU. – 2007. – № 1. – S. 58–60.
5. Likhvantseva V. G., Budzinskaya M. V., Szewczyk S. A. and others. The first clinical experience with photodynamic therapy using a
photosensitizer domestic “Photosens” in oftalmoonkologii//Russian biotherapeutic zhurnal. – 2005. – V. 2, – № 4. – P 39–40.
6. Meerovitch I. G., Stratonnikov A. A., Ryabov A. B. et al. optical absorption studies of sensitizers in biological tissues invivo//Russian
biotherapeutic zhurnal. – 2004. – Vol.3, – № 2. – P. 54–55.
7. Leverage G. P., Russinovich V. M., Ginyuk V. A. On the justification of photodynamic therapy for purulent pathology//Actual problems
of modern surgery: scientific materials. conf., is dedicated. 60th anniversary of prof. YS Vinnika. – M. – Krasnoyarsk, – 2008.- S. 387–391.
8. Sadykov R. A., Kasymov K. R., Sadykov R. R. Technical and scientific aspects of the photodynamic terapii. – Tashkent, – 2012. – 167 p.
9. Sumlin R. M., Stenko A. A., Beetle I. G., Braga M. Y. The main directions of photodynamic therapy in medicine//News hirurgii. –
2008. – № 3. – S. 155–162.
10. Luksiene Z., ZukauskasA. Prospects of photosensitization in control of pathogenic and harmful microorganisms//Journal of Applied
Microbiology. – 2009. – № 3. – P. 1–6.
11. Spaide R., Sorenson J., Maranan L. Photodynamic therapy with verteporfin combined with intravitreal injection of triamcinolone
acetonide for choroidal neovascularization//Ophthalmology. – 2005. – Vol. 112 (2). – P. 301–304. (27).
12. Tavares A., CarvalhoC., Faustino M.et al.Antimicrobial photodynamic therapy: study of bacterial recovery viability and potential
development of resistance after treatment//Mar. Drugs. – 2010. – Vol. 8. – P. 91–105.