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European Science Review, Issue 9-10/2016

Efficacy and safety of highly active antiretroviral therapy comprising tenofovir in patients with HIV infection

DOI: https://doi.org/10.29013/ESR-16-9.10-79-81

Pages: 79 - 81

Authors: Bayjanov A. K.

Abstract: The objective of the study was to evaluate the effectiveness and safety of highly active antiretroviral therapy regimens containing tenofovir — TDF in HIV patients. Three classes of antiretroviral agents today are commonly used for the specific treatment of patients with HIV: nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors (1, 5, 7). The other drugs of the same class — nucleoside reverse transcriptase inhibitors — were developed in the following years (3, 4). One of the current nucleoside reverse transcriptase inhibitor is Tenofovir (2). Inclusion of Tenofovir drug into antiretroviral therapies leads to suppression of the replicative capacity of human immunodeficiency virus. The nucleoside inhibitors bind stronger to reverse transcriptase than to host cell DNA polymerases. This provides them with a relatively selective effect on the virus. The drug Tenofovir (TDF) in 2001 was approved for use as part of antiretroviral therapy (ART) for the treatment of patients with HIV infection (6).

Keywords: antiretroviral therapy, tenofovir, viral load, nucleotide and non-nucleoside reverse transcriptase inhibitor

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