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European Science Review, Issue 9-10/2016

Animal models of peritonitis

DOI: https://doi.org/10.29013/ESR-16-9.10-65-70

Pages: 65 - 70

Authors: Aripov U. R., Rasul S.

Abstract: Understanding the role of pathogens and endotoxin in peritonitis and its complications may improve accuracy of diagnosis and development of therapeutic options. The etiology of peritonitis is multifactorial and affects cardiovascular, immunological and endocrine systems of the human body. Animal models are the essential contributor in the evaluation of efficacy and safety of potential therapeutic agents. However, their physiological limitations often restrict their usefulness and cause barriers to translate study results into clinical practice. Careful differentiation of models can help study different aspects of the disease. Evidence-based information could potentially contribute to the interpretation of results of animal studies, which can be successfully used in clinical trials

Keywords: peritonitis, spontaneous bacterial peritonitis (SBP), infections, sepsis, immune system, lipopolysaccharide (LPS), endotoxins, zymosan, inflammation, Toll-like receptor 4 (TLR4), Tumour Necrosis Factor alpha (TNF-α), Interleukin, Polymorphonuclear Leukocytes (PMNs), macrophages, cytokines, cecal ligation and puncture (CLP).

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