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European Science Review, Issue 9-10/2016

Phenotypic and genotypic resistance to antimicrobial performance in stains of Salmonella Typhimurium

DOI: https://doi.org/10.29013/ESR-16-9.10-49-51

Pages: 49 - 51

Authors: Abdukhalilova G., Tuhtamurodov H., Ibragimov A., Ahmedov I., Gulyamov N. G.

Abstract: We studied 39 strains of Salmonella Typhimurium, which were allocated from patients in 2012–2013 by bacteriological and molecular genetic methods, strains sensitivity to antimicrobial agents. It revealed an extremely high proportion of strains resistant to the antibiotic medicines, including — β-lactams (84.6%) and fluoroquinolones (92.3%). Strains of S. Typhimurium characterized by multiple resistances to different classes of the antibiotics. About half of the isolates (43.6%) have the same resistance phenotype A‑AC-T‑C–CO-CTX–CA-NA-CPM, which may indicate the clonal propagation of the pathogen. Resistant strains of S. Typhimurium to β-lactams (including cephalosporins of 3–4 generations) is due to produce β-lactamase Sectiom 6. Medical science 50 genetic families TEM and CTX–M, with 66,7% of the strains are characterized by the same genotype and resistance genes have four β-lactamases: TEM, CTX–M1, CTX–M2 and CTX–M25, it can also indicate the clonal propagation of the pathogen

Keywords: antibiotic, resistance, gen, phenotype, genotype, S. Тyphimurium.Introduction

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